The Synergy of CBD Botanicals

The Synergy of CBD Botanicals

The Synergy of CBD Botanicals is the essence of what Green Earth Medicinals is all about. We strive to produce carefully formulated products that are designed to provide you with a healthier tomorrow. We believe in a world with limitless potential for one’s health and how we care for ourselves. Utilizing full-spectrum CBD Hemp extract allows us to capture a wide array of compounds with the combined effect of yielding higher levels of efficacy. We are extremely intentional in adding other botanical extracts into our formulas to enhance efficacy, increase absorption, and to target specific symptoms.

synergy of botanicals

If you take the time to review each of our product specifications, our formulators explain how these botanicals may affect your body. This Spring, in our Herbarium posts, we’ll be diving further into our unique array of ingredients to give our customers an immersive explanation of what goes into each formula.

Jason Miller and Christian Le in the lab

We believe in harnessing the accumulated wisdom of our ancestors with the aid of modern science and clinical experience. Our formulas go beyond CBD and the entourage effect of full-spectrum hemp to include the healing potential of over 30 additional botanicals.

We add botanicals to our CBD formulas for three interwoven reasons:

  1. To enhance efficacy: Botanicals can be added to CBD formulas to increase specific desired effects. For instance, our CBD Oral Spray contains kava (Piper methysticum), an herb revered in Polynesia for its mild sedative and euphoric properties. Kava helps to enhance those same calming and focusing properties that are found in CBD.1-3
  2. To increase absorption: CBD is a fat-soluble molecule that can be difficult for the body to absorb. The addition of tangerine (Citrus reticulata), which is an excellent source of limonene (>90%), helps open pores in the skin and mucous membranes to allow CBD to penetrate to deeper layers where it’s needed most.4-7
  3. To target specific systems: Certain herbs, when combined with CBD, can help direct CBD to specific body systems. An example of this is Asian corydalis (Corydalis yanhusuo), an herb used in Traditional Chinese Medicine to alleviate pain. When added to our Relief Cream, Asian corydalis helps direct CBD to the pain response system, amplifying its pain-relieving potential.8-9

This Spring, the Herbarium will be featuring individual ingredient spotlights. If you’re interested in learning more about a specific ingredient or topic our ears are always open, please reach out via

Green Earth Medicinals ingredients

Feb 2020


1 Chua HC, Christensen ET, Hoestgaard-Jensen K, Hartiadi LY, Ramzan I, Jensen AA, Absalom NL, Chebib M. Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism. PLoS One. 2016;11(6):e0157700. doi: 10.1371/journal.pone.0157700. eCollection 2016. PubMed PMID: 27332705; PubMed Central PMCID: PMC4917254.

2Garrett KM, Basmadjian G, Khan IA, Schaneberg BT, Seale TW. Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice. Psychopharmacology (Berl). 2003 Oct;170(1):33-41. doi: 10.1007/s00213-003-1520-0. Epub 2003 Jul 4. PubMed PMID: 12845414.

3Singh YN, Singh NN. Therapeutic potential of kava in the treatment of anxiety disorders. CNS Drugs. 2002;16(11):731-43. doi: 10.2165/00023210-200216110-00002. Review. PubMed PMID: 12383029.

4 Rangsimawong W, Obata Y, Opanasopit P, Ngawhirunpat T, Takayama K. Enhancement of Galantamine HBr Skin Permeation Using Sonophoresis and Limonene-Containing PEGylated Liposomes. AAPS PharmSciTech. 2018 Apr;19(3):1093-1104. doi: 10.1208/s12249-017-0921-z. Epub 2017 Nov 22. PubMed PMID: 29168128.

5 Herman A, Herman AP. Essential oils and their constituents as skin penetration enhancer for transdermal drug delivery: a review. J Pharm Pharmacol. 2015 Apr;67(4):473-85. doi: 10.1111/jphp.12334. Epub 2014 Dec 31. Review. PubMed PMID: 25557808.

6 Okabe H, Takayama K, Ogura A, Nagai T. Effect of limonene and related compounds on the percutaneous absorption of indomethacin. Drug Des Deliv. 1989 Jun;4(4):313-21. PubMed PMID: 2775451.

7 Muhammad F, Jaberi-Douraki M, de Sousa DP, Riviere JE. Modulation of chemical dermal absorption by 14 natural products: a quantitative structure permeation analysis of components often found in topical preparations. Cutan Ocul Toxicol. 2017 Sep;36(3):237-252. doi: 10.1080/15569527.2016.1258709. Epub 2016 Dec 14. PubMed PMID: 27825281.

8 Yuan CS, Mehendale SR, Wang CZ, Aung HH, Jiang T, Guan X, Shoyama Y. (2004). Effects of Corydalis yanhusuo and Angelicae dahuricae on cold pressor-induced pain in humans: a controlled trial., J Clin Pharmacol. 2004 Nov;44(11):1323-7.

9 Lin DZ, Fang YS. (1990). Modern Study and Application of Materia Medica. Hong Kong: China Ocean Press, 1990, 323–5.